Doctors often use Modified Marsh classification based on histopathology to understand various levels of intestinal damage identified in biopsy.
Stage 0 – Pre infiltrative mucosa considered as normal.
Stage 1 – Increase in the number of intraepithelial lymphocytes (IELS) to more than 25 per 100 electrolytes with a normal crypt/villi ratio.
Stage 2 – In addition to the increased IELS, there is an increase in crypt depth without a reduction in villus height. This is known as crypt hyperplasia.…