Skip to main content
Submitted by PatientsEngage on 19 April 2017

WORLD LIVER DAY

Did you know Type 2 diabetes (T2D), insulin resistance, obesity, metabolic syndrome and NAFLD (Non Alchoholic Fatty Liver Disease) are particularly closely related? Dr Parijat Gupte, Consultant Hepatologist or Liver Specialist, provides us with a basic knowledge on NAFLD and what it can signify.

What Is NAFLD?

In simple terms, NAFLD or non-alcoholic fatty liver disease is abnormal or excess accumulation of fat in the liver. Normally, liver does not contain more than 0-5% fat. The most common cause of fatty liver is excess alcohol consumption. As its name suggests, it is the deposition of excess fat in the liver without intake of excess of alcohol(Non Alcoholic).

How it is different from AFLD(Alcoholic fatty liver disease)?

It has clinical resemblances with alcoholic fatty liver disease, and it shares commonalities as far as investigations go as well. It is often difficult to differentiate between the two, specially if the patient does not divulge any history of alcohol intake. Some clinical features (large liver), clues in blood tests -- very high levels of GGT (Gamma-glutamyl transpeptidase), High MCV (Mean corpuscular volume ) -- and other features on liver biopsy may help differentiate the two.

Who is most at risk of getting NAFLD?

Patients who are obese, suffer from diabetes, high cholesterol and hypertension are the ones most at risk. Some lean individuals or those with a family history of fatty liver disease can also develop fatty liver disease. Women with PCOS ( Polycystic ovary syndrome) commonly have fatty liver.

Are all people with diabetes screened for it? Why?

Fatty liver is found in approximately 40% of diabetics. Patients with diabetes should undergo screening for NAFLD. Presence of fatty liver does not necessarily mean serious liver disease, but it needs further investigations and follow up at regular intervals.

Is it a growing concern in the Indian population?

As diabetes has one of the highest records in India and obesity is also on the rise, changing dietary patterns combined with a sedentary lifestyle has resulted in a steady increase of NAFLD cases.

How is it usually diagnosed?

It is best diagnosed on sonography of the liver. One may suspect fatty liver disease if liver function tests done for any reason are found to be consistently abnormal. It may be the cause of liver disease in an individual who has risk factors and does not have any other obvious cause for his liver disease.

What is the common line of treatment?

Slow, progressive and sustained weight loss of about 5-10% of current body weight is the most important and effective line of treatment.

It should also be combined with a moderate degree of exercise. A mix of aerobic (brisk walking etc.) and anaerobic exercise for 30 minutes for at least 3-4 times a week is recommended. Exercise type and duration should be decided after medical assessment and evaluation for heart disease.

Some patients may be helped with Vitamin E or certain group of antidiabetics. But medical therapy is secondary, short term and is advisable only after expert consultation.

What is the biggest complication of a liver disease?

Serious liver disease can occur in about 5- 10% patients who have fatty liver disease. Patients who have fatty liver are at risk of developing coronary artery disease (heart disease) as risk factors for these diseases are common.

Is weight loss surgery recommended for all patients?

Weight loss surgery is recommended only for those who are morbidly obese, or those who are obese and have severe metabolic complications. It should be performed only after medical and dietary approaches have failed or found to be inadequate. Prior evaluation by an endocrinologist, a gastroenterologist, a nutritionist and even a psychiatrist is mandatory before deciding on surgery.

Dr Parijat Gupte is a Consultant Hepatologist or Liver Specialist who works with several hospitals including the Global Hospital in Mumbai.

Stories

  • 9 reasons to get off that couch NOW
    Think you know all the reasons? Prepare to be surprised. By family practitioner and marathoner Dr Gita Mathai. Plus, how much to exercise to get its real benefits. We all want to look good, be slim and healthy. There’s one magic pill for this and it’s called exercise. Even if you’re ‘too tired’ or ‘too busy’, you need to get off that couch now.  Benefits of regular exercise Exercise helps to achieve ideal body weight if also combined with calorie restriction.…
  • Hope in the battle against bulging waistlines
    More than 2.1 billion people, or nearly 30% of the global population, are overweight or obese. Excess weight leads to about 5% of worldwide deaths. On current trends, almost half of the world’s adults will be fat by 2030. Over the past three decades, according to a study in the Lancet, a medical journal, no nation has slimmed down. But a new study from the McKinsey Global Institute (MGI), the consultancy’s research arm, offers some hope. It looks at 74 anti-obesity measures around the…
  • Yoga comparable with walking, biking to improve cardiovascular risk
    Yoga has roots as an ancient mind-body practice that incorporates physical, mental and spiritual elements. Originating in India, yoga has been proven effective in numerous studies to improve cardiovascular risk factors, with a reduction in the risk of heart attacks and strokes. When compared with no exercise, yoga was associated with significant improvement in each of the primary outcome risk factors measured: Body mass index (BMI) reduced by 0.77 kg/m2 (measured as a "mean…
  • Let your doctor know : Diabetes and Natural remedies
    It is important that the physician is kept updated about the natural remedies a diabetic is trying out. When managing blood sugar levels becomes a daily battle that tests one’s will and wits, a little help on the side certainly helps. Herbs, spices, botanicals, Chinese herbs, fish oil therapy, chromium picolinate — the list can be endless, not to mention the innumerable diabetes “supplements” available over the counter. Complementary and alternative medicines for diabetes are immensely…
  • Jakarta’s young working generation increasingly prone to diabetes
    While this is a news item about Jakarta, it could well be about the youth of Mumbai, Delhi, Singapore.. Nurul Ratna Manikam, a Clinical nutritionist at Cipto Mangunkusumo General Hospital in Central Jakarta, said that most of her young patients worked an 8 a.m. to 5 p.m. shift and spent their mornings and nights commuting to and from their offices. They also spend most of their time sitting on a chair behind their desks or standing inside a bus or train and did not have time to…
  • Imaging Willpower: Using Brain Scans to Explore Obesity
    For some people, the smell of good food can trigger a feeding frenzy. But others find it much easier to resist such temptations. What’s the explanation? Is it willpower ? A recent study in the journal Molecular Psychiatry suggests the answer to what fuels susceptibility to food cues may be far more complex, related to subtle differences in brain chemistry. The PET scans showed that, compared to their leaner counterparts, obese individuals had more dopamine-triggered signaling activity in…
  • Tears of a Clown
    Christina Kim, long one of the LPGA Tour's most effervescent personalities, opens up about her battle with depression. "I felt like all the fun and joy was suffocating me," she says now. "I looked down, and the water seemed very inviting, even though I can't swim. The solitude and silence that I was seeking, which I couldn't find anywhere in the building because everyone was laughing and living life and being happy, seemed to be in the water." She thought it over, stood there for about 15…
  • Diabetes FAQ - Questions that you wanted to ask but never did
    Based on a discussion with Dr. Venkat Rao, Diabetologist 1. My mother has diabetes. Should I get my blood sugar checked? I am now 30 years old.  Everybody should get their blood sugar tested once a year after the age of 30, irrespective of whether or not there is a family history of diabetes. This is especially true for Indians as India has a high incidence of diabetes.  If you have a family history of diabetes with a tendency of early occurrence; if you are obese…
  • Mediterranean diet is best way to tackle obesity, say doctors
    A Mediterranean diet may be a better way of tackling obesity than calorie counting, leading doctors have said. Writing in the Postgraduate Medical Journal (PMJ), the doctors said a Mediterranean diet quickly reduced the risk of heart attacks and strokes. The PMJ editorial argues a focus on food intake is the best approach, but it warns crash dieting is harmful. They criticise the weight-loss industry for focusing on calorie restriction rather than "good nutrition". And they make the case…
  • For 13 years she was afraid of telling people she had Type 2 Diabetes
    Today Juliana Lim from Singapore is a team leader in a Diabetes Support Group inspiring others to be open about their condition. Read about her inspiring story